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How Flow works

1. Own or rent your device

2. Get the app to learn and make behaviour changes

3. Stimulate with the headset 2-5 times per week

4. Reduce depressive symptoms in 6 weeks

Why Flow works

Flow combines brain stimulation and behaviour therapy in a headset and app treatment programme to reduce depression and increase positive routine.

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Flow and the brain

Depression is associated with lowered activity in the Dorsolateral Prefrontal Cortex, located in the frontal lobe of the brain. The Flow headset delivers gentle electrical signals here to restore activity in brain cells, resulting in a reduction of depressive symptoms.

This technique is called transcranial Direct Current Stimulation (tDCS), a long-used technology in clinics and now with Flow it’s available for home use in a medically-certified compact device.

The Flow treatment consists of 30 minute stimulation sessions. You will stimulate 5 times per week for the first 3 weeks and then 1-2 times per week for as long as you need. 85% of Flow users feel a difference in their depression after just 3 weeks

Flow and the brain

Depression is associated with lowered activity in the Dorsolateral Prefrontal Cortex, located in the frontal lobe of the brain. The Flow headset delivers gentle electrical signals here to restore activity in brain cells, resulting in a reduction of depressive symptoms.

This technique is called transcranial Direct Current Stimulation (tDCS), a long-used technology in clinics and now with Flow it’s available for home use in a medically-certified compact device.

The Flow treatment consists of 30 minute stimulation sessions. You will stimulate 5 times per week for the first 3 weeks and then 1-2 times per week for as long as you need. 85% of Flow users feel a difference in their depression after just 3 weeks

Flow and your behaviour

To maximize your chances of recovering from depression, the Flow brain stimulation is combined with a behaviour therapy app. Our in-house licensed Psychologists have created a plan that ensures the activity restoration in your brain is accompanied by long-term habit changes.

Behaviours such as getting enough sleep, moving your body, eating well and meditating have been proven to have a significant impact on depression.

The techniques used in the Flow app are based on RCTs (Randomised Controlled Trials) from the field of clinical psychology and are administered by a virtual therapist. You can schedule, access and go-back to any exercises at your own pace, from your own home.

App store rating: 4.6
4.6/5

Scientific evidence

Most recent meta-analyses show that the technique used in the Flow headset can reduce depressive symptoms by half after six weeks of treatment.

Research at Flow Neuroscience

Internal research reveals that 81% of Flow users have experienced a reduction in their depression after only three weeks.

Safety

Flow is a CE certified treatment, meaning that it is approved for medical use and compliant with European protective laws for medical devices.

The certification validates that Flow is based on scientific evidence, can reduce depressive symptoms and that the headset is safe to use.

Side effects

The Flow headset has similar efficacy to other treatments for depression but with less severe side effects. You might experience a slight tingle on your skin or redness around the area where the electrodes are placed – both are completely normal and harmless.

Using Flow poses minimal risk of harm, however it is recommended that you consider multiple treatment options. If symptoms worsen, make sure to contact a healthcare professional. We recommend always having ongoing contact with a healthcare professional if you suffer from depression.
If you suffer from depression and are seeking treatment we recommend having ongoing contact with a healthcare professional. Flow can be integrated as part of your current care plan or on it’s own.

Get Flow

Rent or Own. Choose your Flow with flexibility.

Clinical Research: Brain Stimulation

The Flow brain stimulation treatment is based on decades of clinical research with the most recent meta-analyses showing that tDCS has similar efficacy to other treatments but with fewer side effects

Across 20+ randomized controlled trials tDCS has been shown to be superior to placebo/sham and no serious adverse events have been observed. Hence, tDCS provides an alternative to medication that is effective, safe and accessible.

tDCS is comparable to antidepressants and TMS in treating depression
An analysis of 23 clinical trials with 1092 patients, showing that tDCS is superior to placebo/sham
No serious adverse events were found across 33,200 tDCS sessions with 1000 users
Study including 245 patients, comparing tDCS with a common antidepressant
tDCS was found to be efficacious and comparable to TMS
Combining tDCS and a common antidepressant increases the efficacy of each treatment
30-minute tDCS sessions lead to better outcomes than 20-minutes sessions
Side effects from tDCS are mild, transient and well-tolerated
tDCS is efficient in cases where antidepressants don’t work
Low-energy brain stimulation is safe to use
tDCS is safe and effective for treating depression
tDCS is a safe long-term follow-up treatment

Clinical Research: Behaviour Therapy

The Flow therapy app is based on a hundred years of psychological research, showing that exercise, sleep, diet and meditating all have an impact on reducing depressive symptoms when incorporated into a regular routine.

Exercise​

Research shows that regular exercise is as effective as antidepressant medication. It increases positive mood and stimulates growth of new brain cells.

Meditation
Daily meditation enhances your mood, attention, memory and emotional regulation while reducing depressive symptoms.
Nutrition​

The latest research gives you the recipe for an antidepressant diet. Changing your eating habits can prevent the development of depression and reduce depressive symptoms.

Sleep​
Did you know that sleep can act as overnight therapy? According to research, creating healthy sleeping habits can impact depressive symptoms.

Exercise​

Murri et al., 2019: Physical Exercise in Major Depression: Reducing the Mortality Gap While Improving Clinical Outcomes. 

Hallgren et al., 2020: Associations of exercise frequency and cardiorespiratory fitness with symptoms of depression and anxiety – a cross-sectional study of 36,595 adults.

Morres et al., 2018: Aerobic exercise for adult patients with major depressive disorder in mental health services: A systematic review and meta‐analysis.

Lederman et al., 2019: Does exercise improve sleep quality in individuals with mental illness? A systematic review and meta-analysis.

Basso & Suzuki, 2017: The Effects of Acute Exercise on Mood, Cognition, Neurophysiology, and Neurochemical Pathways: A Review.

Schuch et al., 2016: Exercise as a treatment for depression: A meta-analysis adjusting for publication bias

Meditation

Basso et al., 2018: Brief, daily meditation enhances attention, memory, mood, and emotional regulation in non-experienced meditators.

Li et al., 2020: Effects of mindfulness meditation on anxiety, depression, stress, and mindfulness in nursing students: a meta-analysis and trial sequential analysis of randomized controlled trials.

Reangsing et al., 2020: Effects of mindfulness meditation interventions on depression in older adults: A meta-analysis.

Carpena et al., 2019: The effect of a six-week focused meditation training on depression and anxiety symptoms in Brazilian university students with 6 and 12 months of follow-up.

Fish & Saul, 2019: The Gamification of Meditation: A Randomized-Controlled Study of a Prescribed Mobile Mindfulness Meditation Application in Reducing College Students’ Depression.

Kuyken et al., 2016: Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse

Do-Hyung Kang et al., 2013: The effect of meditation on brain structure: cortical thickness mapping and diffusion tensor imaging

Farb et al., 2010: Minding one’s emotions: Mindfulness training alters the neural expression of sadness

Nutrition

Bastiaanssen et al., 2020: Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder

 

Lassale et al., 2019: Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies

 

Dinan et al., 2018: Feeding melancholic microbes: MyNewGut recommendations on diet and mood.

 

Godos et al., 2019: Adherence to the Mediterranean Diet is Associated with Better Sleep Quality in Italian Adults

 

Jacka et al., 2017: A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)


Vermeulen et al., 2017: A combined high-sugar and high-saturated-fat dietary pattern is associated with more depressive symptoms in a multi-ethnic population: the HELIUS (Healthy Life in an Urban Setting) study

Sleep

Riemann et al., 2020: Sleep, insomnia and depression 

 

Üzer & Yücens, 2020: The effect of circadian preferences on insomnia severity and depressive symptoms via sleep hygiene in older adults with depression and healthy controls.

 

Lane et al., 2019: Biological and clinical insights from genetics of insomnia symptoms.

 

Tolêdo et al., 2020: Sleep disturbance and depression in adolescence: an integrative review of literature

 

van der Helm & Walker, 2009: Overnight Therapy? The Role of Sleep in Emotional Brain Processing.

 

Nishida et al., 2009: REM Sleep, Prefrontal Theta, and the Consolidation of Human Emotional Memory.


Tsuno et al., 2005: Sleep and Depression.

tDCS and depression

tDCS has shown across years of research to be effective in reducing depressive symptoms. With world-leading tDCS researcher Andre Brunoni highlighting that tDCS works best through 30-minute sessions, 2-5 times per week. In terms of adverse experiences, recent meta-analyses indicate that this type of treatment has low risk, with over 33200 stimulation sessions showing no serious effects.

Flow and depression

The Flow treatment has proven effective, both by research trials conducted by third parties and by internal analysis conducted by Flow Neuroscience.
The Flow treatment has been shown in multiple clinical trials to have a positive impact on depression and to reduce depressive symptoms within 3 weeks.
Internal analysis shows 81% of Flow users experiencing an increase in focus, mood and optimism with 30% overcoming depression completely.

Clinical Research Pillars

As part of our commitment to the field of brain stimulation and mental health, we are focused on creating accessible solutions globally that have an impact.

Research Community

We are committed to our research contribution and are proud to partner with:

Get Flow

Rent or Own. Choose your Flow with flexibility.